Ccr2^{tm1(cre/ERT2,mKate2)Arte}
Targeted Allele Detail

Summary

• Symbol: Ccr2^{tm1(cre/ERT2,mKate2)Arte}
• Name: C-C motif chemokine receptor 2; targeted mutation 1, TaconicArtemis
• MGI ID: MGI:6314378
• Synonyms: Ccr2^{tm2982(T2A-Cre7ESR1-T2A-mKate2)BB}, Ccr2^{tm2982(T2A-Cre/ESR1-T2A-mKate2)Arte}
• Gene: Ccr2 Location: Chr9:123901987-123913594 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr2^{tm1(cre/ERT2,mKate2)Arte} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233647
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Ccr2^{tm1(cre/ERT2,mKate2)Arte} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ccr2 (MGI:106185)

• Mutation details: A targeting vector containing an FRT-flanked puromycin resistance gene upstream of exon 3, followed by T2A, a Cre recombinase/ERT2 fusion, a second T2A sequence, and the monomeric far-red fluorescent protein mKate2 was inserted into the 3' UTR (downstream of exon 3) of the Ccr2 gene. (J:233647)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ccr2 (mouse) Summary of all recombinase alleles driven by Ccr2. Alliance mouse Ccr2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ccr2 Mutation: 43 strains or lines available

References

• Original: J:233647 Croxford AL, et al., The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity. Immunity. 2015 Sep 15;43(3):502-14
• All: 12 reference(s)