Rev3l^tm1Crey
Targeted Allele Detail

Summary

• Symbol: Rev3l^tm1Crey
• Name: REV3 like, DNA directed polymerase zeta catalytic subunit; targeted mutation 1, Claude-Agnes Reynaud
• MGI ID: MGI:6316682
• Synonyms: Rev3l^ATA
• Gene: Rev3l Location: Chr10:39608114-39751207 bp, + strand Genetic Position: Chr10, 21.04 cM
• Alliance: Rev3l^tm1Crey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276485
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: This mutation bears the two substitutions D2773A and D2775A in the sequences encoding the catalytic domain. (J:276485)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rev3l Mutation: 120 strains or lines available

References

• Original: J:276485 Fritzen R, et al., A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro. DNA Repair (Amst). 2016 Oct;46:37-46
• All: 1 reference(s)