Pcdha^tm13Tyag
Targeted Allele Detail

Summary

• Symbol: Pcdha^tm13Tyag
• Name: protocadherin alpha cluster; targeted mutation 13, Takeshi Yagi
• MGI ID: MGI:6331270
• Synonyms: alpha1MV
• Gene: Pcdha Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240639
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change, Reporter)
• Mutation: Insertion
• Mutation details: Using mouse BAC RP23-303I8, this allele has a loxP and FRT site flanked neomycin resistance gene cassette inserted upstream of, and a myc-tagged Venus fluorescent protein gene cassette inserted into, the 5' end of the first exon, alpha1, of the first gene in the cluster, Pcdha1. (J:240639, J:244163)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcdha Mutation: 52 strains or lines available

References

• Original: J:240639 Tarusawa E, et al., Establishment of high reciprocal connectivity between clonal cortical neurons is regulated by the Dnmt3b DNA methyltransferase and clustered protocadherins. BMC Biol. 2016 Dec 02;14(1):103
• All: 3 reference(s)