Cldn3^tm1.1Hedv
Targeted Allele Detail

Summary

• Symbol: Cldn3^tm1.1Hedv
• Name: claudin 3; targeted mutation 1.1, Helga E de Vries
• MGI ID: MGI:6333006
• Gene: Cldn3 Location: Chr5:135015068-135016326 bp, + strand Genetic Position: Chr5, 74.93 cM
• Alliance: Cldn3^tm1.1Hedv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A single loxP site was inserted upstream of the single exon and a frt-flanked neomycin resistance cassette followed by another loxP site were inserted downstream of exon 1. Cre-mediated recombination removed the floxed region. (J:277267)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cldn3 Mutation: 11 strains or lines available

References

• Original: J:277267 Kooij G, et al., Disturbed function of the blood-cerebrospinal fluid barrier aggravates neuro-inflammation. Acta Neuropathol. 2014 Aug;128(2):267-77
• All: 4 reference(s)