Dusp9^tm2.1Skey
Targeted Allele Detail

Summary

• Symbol: Dusp9^tm2.1Skey
• Name: dual specificity phosphatase 9; targeted mutation 2.1, Stephen M Keyse
• MGI ID: MGI:6342137
• Synonyms: Dusp9^fl
• Gene: Dusp9 Location: ChrX:72683025-72687120 bp, + strand Genetic Position: ChrX, 37.37 cM, cytoband B
• Alliance: Dusp9^tm2.1Skey page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277326
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 and 4 were flanked by loxP sites and an FRT-flanked puromycin resistance cassette was inserted downstream of exon 4 and immediately 5 to the loxP site within the 3' untranslated region. Flp-mediated recombination removed the selection marker leaving exons 3-4 floxed. (J:277326)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dusp9 Mutation: 27 strains or lines available

References

• Original: J:277326 Niedzielska M, et al., Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-beta Production. J Immunol. 2015 Aug 15;195(4):1753-62
• All: 1 reference(s)