Il36a^tm1Gsk
Targeted Allele Detail

Summary

• Symbol: Il36a^tm1Gsk
• Name: interleukin 36A; targeted mutation 1, GlaxoSmithKline Plc
• MGI ID: MGI:6342261
• Synonyms: IL-36alpha KO
• Gene: Il36a Location: Chr2:24105429-24115713 bp, + strand Genetic Position: Chr2, 16.26 cM, cytoband A3
• Alliance: Il36a^tm1Gsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A null mutation was generated via standard homologous recombination eliminating the mRNA nucleotides 121-263, NM_019450.3. Consequently, part of the 5' UTR and the first 34 codons are absent from the targeted gene. (J:227570)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il36a Mutation: 12 strains or lines available

References

• Original: J:227570 Milora KA, et al., Unprocessed Interleukin-36alpha Regulates Psoriasis-Like Skin Inflammation in Cooperation With Interleukin-1. J Invest Dermatol. 2015 Dec;135(12):2992-3000
• All: 2 reference(s)