Tctn3^tm1.1Blnw
Targeted Allele Detail

Summary

• Symbol: Tctn3^tm1.1Blnw
• Name: tectonic family member 3; targeted mutation 1.1, Baolin Wang
• MGI ID: MGI:6343516
• Synonyms: Tctn3 cko (neo-)
• Gene: Tctn3 Location: Chr19:40584890-40600677 bp, - strand Genetic Position: Chr19, 34.25 cM
• Alliance: Tctn3^tm1.1Blnw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:249241
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An frt-flanked neomycin selection cassette and a loxP site were inserted upstream of exon 3, and a second loxP site was inserted 5' to exon 3. The frt-flnaked neomycin selecction cassette was removed via FLP-mediated recombination. (J:249241)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tctn3 Mutation: 19 strains or lines available

References

• Original: J:249241 Wang C, et al., Three Tctn proteins are functionally conserved in the regulation of neural tube patterning and Gli3 processing but not ciliogenesis and Hedgehog signaling in the mouse. Dev Biol. 2017 Oct 1;430(1):156-165
• All: 1 reference(s)