Cxcl12tm1.2Spo
Targeted Allele Detail
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Symbol: |
Cxcl12tm1.2Spo |
Name: |
C-X-C motif chemokine ligand 12; targeted mutation 1.2, S Paul Oh |
MGI ID: |
MGI:6355999 |
Synonyms: |
Cxcl121loxP(1f) |
Gene: |
Cxcl12 Location: Chr6:117145496-117158328 bp, + strand Genetic Position: Chr6, 54.81 cM, cytoband F1
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Alliance: |
Cxcl12tm1.2Spo page
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Germline Transmission: |
Earliest citation of germline transmission:
J:275512
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An frt-SD/SA-IRES-LacZ-Neo-frt-loxP (LacZ/Neo) cassette including a reporter (LacZ) and a positive selection marker was inserted 923-bp downstream of exon 2. A loxP sequence was cloned 278-bp upstream of exon 2. Cre-mediated recombination of flanking loxP sites resulted in deletino of exon 2 and the lacZ/neo cassette.
(J:275512)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cxcl12 Mutation: |
24 strains or lines available
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Original: |
J:275512 Kim BG, et al., CXCL12-CXCR4 signalling plays an essential role in proper patterning of aortic arch and pulmonary arteries. Cardiovasc Res. 2017 Nov 1;113(13):1677-1687 |
All: |
1 reference(s) |
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