Tcaf3^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tcaf3^em1Cya
• Name: TRPM8 channel-associated factor 3; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6356831
• Synonyms: Tcaf3^em1Cgen, Tcaf3^tm1
• Gene: Tcaf3 Location: Chr6:42564147-42574306 bp, - strand Genetic Position: Chr6, 20.8 cM
• Alliance: Tcaf3^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 mediated mutagenesis induced a 39 bp deletion, corresponding to the region encoding the codons 646-658 of the peptide. (J:258941)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tcaf3 Mutation: 54 strains or lines available

References

• Original: J:258941 Leonard JD, et al., Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen. Immunity. 2017 Jul 18;47(1):107-117.e8
• All: 1 reference(s)