Ifitm3^em1Jsy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ifitm3^em1Jsy
• Name: interferon induced transmembrane protein 3; endonuclease-mediated mutation 1, Jacob S Yount
• MGI ID: MGI:6362958
• Gene: Ifitm3 Location: Chr7:140589503-140590657 bp, - strand Genetic Position: Chr7, 86.25 cM, cytoband F5
• Alliance: Ifitm3^em1Jsy page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 53 bp deletion in exon 1 generating a frameshift which results in a nonsense mutation at codon 18 and a subsequent stop codon at position 37. Protein is not detected by immunoblotting of tissue or cell lysates derived from homozygous mice. (J:279294)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifitm3 Mutation: 25 strains or lines available

References

• Original: J:279294 Kenney AD, et al., IFITM3 protects the heart during influenza virus infection. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18607-18612
• All: 3 reference(s)