Il2rg^em1Hwl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il2rg^em1Hwl
• Name: interleukin 2 receptor, gamma chain; endonuclease-mediated mutation 1, Han-Woong Lee
• MGI ID: MGI:6363061
• Gene: Il2rg Location: ChrX:100307991-100311861 bp, - strand Genetic Position: ChrX, 43.9 cM
• Alliance: Il2rg^em1Hwl page

Mutation origin

• Strain of Origin: C57BL/6JBomTac

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to create a deletion of 11 base pairs in exon 2, which created a frameshift mutation and a premature stop codon. (J:265348)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il2rg Mutation: 179 strains or lines available

References

• Original: J:265348 Lee JH, et al., Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9-mediated gene knockout. Transgenic Res. 2018 Jun;27(3):241-251
• All: 1 reference(s)