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Tnfrsf9tm1c(EUCOMM)Wtsi
Targeted Allele Detail
Summary
Symbol: Tnfrsf9tm1c(EUCOMM)Wtsi
Name: tumor necrosis factor receptor superfamily, member 9; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6363081
Synonyms: Tnfrsf9fl
Gene: Tnfrsf9  Location: Chr4:151004612-151030561 bp, + strand  Genetic Position: Chr4, 81.52 cM
Alliance: Tnfrsf9tm1c(EUCOMM)Wtsi page
IMPC: Tnfrsf9 gene page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:277994
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 151017035 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 151017840. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:277994)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf9 Mutation:  49 strains or lines available
References
Original:  J:277994 Buchan SL, et al., Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function. Immunity. 2018 Nov 20;49(5):958-970.e7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory