Pde4d^tm1.1Jmod
Targeted Allele Detail

Summary

• Symbol: Pde4d^tm1.1Jmod
• Name: phosphodiesterase 4D, cAMP specific; targeted mutation 1.1, James M O'Donnell
• MGI ID: MGI:6363716
• Synonyms: hPDE4D
• Gene: Pde4d Location: Chr13:108790711-110092503 bp, + strand Genetic Position: Chr13, 59.69 cM
• Alliance: Pde4d^tm1.1Jmod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278788
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: Using homologous recombination, tyrosine codon 271 was changed to a phenylalanine codon (p.Y271F). This mutation humanizes the mouse gene since primates have a Y271. An FRT site flanked neomycin resistance gene cassette that was inserted, was removed through subsequent flp-mediated recombination. (J:278788)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde4d Mutation: 182 strains or lines available

References

• Original: J:278788 Zhang C, et al., Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice. Neuropsychopharmacology. 2018 Oct;43(11):2299-2309
• All: 2 reference(s)