Cnr2^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Cnr2^tm1.1Itl
• Name: cannabinoid receptor 2; targeted mutation 1.1, Ingenious Targeting Laboratory
• MGI ID: MGI:6364878
• Synonyms: CB2^flox
• Gene: Cnr2 Location: Chr4:135622705-135647518 bp, + strand Genetic Position: Chr4, 68.01 cM
• Alliance: Cnr2^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278651
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The coding exon 3 of the gene is flanked by loxP sites at the 5' end and a second loxP insertion at downstream of the stop codon so that Cre-mediated recombination will produce a deletion of entire coding region and splicing site. An frt-flanked neomycin selection cassette was removed via Flp-mediated recombination in the germline. (J:278651)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnr2 Mutation: 24 strains or lines available

References

• Original: J:278651 Liu QR, et al., Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference. Sci Rep. 2017 Dec 12;7(1):17410
• All: 2 reference(s)