App^em1H
Endonuclease-mediated Allele Detail

Summary

• Symbol: App^em1H
• Name: amyloid beta precursor protein; endonuclease-mediated mutation 1, Harwell
• MGI ID: MGI:6384251
• Synonyms: APP-MABH-EM1-B6N
• Gene: App Location: Chr16:84751236-84972187 bp, - strand Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
• Alliance: App^em1H page

Mutation origin

• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting produced the amino acid substitutions glycine for arginine at position 601 (G601R), tyrosine for phenylalanine at position 606 (F606Y), and histidine for arginine (R609H). (J:90559)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any App Mutation: 105 strains or lines available

References

• Original: J:90559 The Mammalian Genetics Unit at Harwell, Information obtained from the Mammalian Genetics Unit, Medical Research Council (MRC), Harwell, UK. Unpublished. 2004-2013
• All: 1 reference(s)