Mapk14^tm1.2Lex
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1.2Lex
• Name: mitogen-activated protein kinase 14; targeted mutation 1.2, Lexicon Genetics
• MGI ID: MGI:6385109
• Gene: Mapk14 Location: Chr17:28910303-28967380 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1.2Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert loxP sites flanking exon 1, which contains the start codon of the gene. The construct also included an FRT-flanked neomycin resistance (neo) cassette. FLP-mediated recombination removed the neo cassette. (J:98514)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 41 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Mapk14^tm1Lex, has been analyzed.

References

• Original: J:98514 Engel FB, et al., p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev. 2005 May 15;19(10):1175-87
• All: 2 reference(s)