Mapt^{tm1(MAPT*P301L)Tmi}
Targeted Allele Detail

Summary

• Symbol: Mapt^{tm1(MAPT*P301L)Tmi}
• Name: microtubule-associated protein tau; targeted mutation 1, Tomohiro Miyasaka
• MGI ID: MGI:6389830
• Synonyms: P301L KI
• Gene: Mapt Location: Chr11:104122216-104222916 bp, + strand Genetic Position: Chr11, 67.79 cM, cytoband E1
• Alliance: Mapt^{tm1(MAPT*P301L)Tmi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283607
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mapt^{tm1(MAPT*P301L)Tmi} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

  P301L mutation in the 1N4R isoform

• Mutation details: Human tau cDNA containing the P301L mutation and a floxed PGK-Neo poly-A cassette were inserted in-frame from the endogenous start codon in exon 1 of the gene. The mutant human tau replaces the endogenous mouse tau and is expressed under the mouse tau promoter. (J:283607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapt Mutation: 428 strains or lines available

References

• Original: J:283607 Kubo A, et al., Ectopic Expression Induces Abnormal Somatodendritic Distribution of Tau in the Mouse Brain. J Neurosci. 2019 Aug 21;39(34):6781-6797
• All: 1 reference(s)