Bard1^tm4.1Rjbr
Targeted Allele Detail

Summary

• Symbol: Bard1^tm4.1Rjbr
• Name: BRCA1 associated RING domain 1; targeted mutation 4.1, Richard J Baer
• MGI ID: MGI:6399957
• Synonyms: Bard1^co
• Gene: Bard1 Location: Chr1:71066690-71142300 bp, - strand Genetic Position: Chr1, 35.67 cM
• Alliance: Bard1^tm4.1Rjbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269011
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted approximately 900 bp upstream of the first coding exon and a second loxP site along with a PGK-neomycin resistance cassette flanked by FRT sites was inserted approximately 350 bp downstream of the first coding exon. The selection cassette was removed via Flp-mediated recombination leaving exon 1 flanked by loxP sites. (J:269011)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bard1 Mutation: 55 strains or lines available

References

• Original: J:269011 Billing D, et al., The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection. Mol Cell. 2018 Oct 4;72(1):127-139.e8
• All: 1 reference(s)