Tg(CAG-DPP4)52Ctkt
Transgene Detail

Summary

• Symbol: Tg(CAG-DPP4)52Ctkt
• Name: transgene insertion 52, Chien-Te K Tseng
• MGI ID: MGI:6402051
• Synonyms: line 52 hCD26 Tg⁺
• Transgene: Tg(CAG-DPP4)52Ctkt Location: unknown
• Alliance: Tg(CAG-DPP4)52Ctkt page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H/HeJ)F1 x C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-DPP4)52Ctkt expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DPP4 (1803)

  Dpp4	(MGI:94919)

• Mutation details: The human DPP4 cDNA, the viral receptor of Middle East respiratory-coronavirus (MERS-CoV), generated from the mRNA of human phytohemagglutinin-activated T cells, is under the control of the CAG promoter. (J:258199)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:258199 Agrawal AS, et al., Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease. J Virol. 2015 Apr;89(7):3659-70
• All: 13 reference(s)