Il6^tm2(IL6)Flv
Targeted Allele Detail

Summary

• Symbol: Il6^tm2(IL6)Flv
• Name: interleukin 6; targeted mutation 2, Richard A Flavell
• MGI ID: MGI:6405713
• Synonyms: IL-6^h, Il6^tm2(IL6)Vlcg
• Gene: Il6 Location: Chr5:30218112-30224973 bp, + strand Genetic Position: Chr5, 15.7 cM
• Alliance: Il6^tm2(IL6)Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240722
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: BALB/cAnNTac x 129S4/SvJae

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Il6^tm2(IL6)Flv expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL6 (3569)

  Il6	(MGI:96559)

• Mutation details: The open reading frame was replaced by its human homolog. A floxed neomycin resistance cassette was inserted downstream of the mouse 3' UTR. (J:286575)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il6 Mutation: 38 strains or lines available

Notes

ES cells = F1 BALB/c 129 Rag2^tm1.1Flv heterozygous Il2rg^tm1.1Flv hemizygous

References

• Original: J:240722 Das R, et al., Microenvironment-dependent growth of preneoplastic and malignant plasma cells in humanized mice. Nat Med. 2016 Nov;22(11):1351-1357
• All: 4 reference(s)