Gt(ROSA)26Sor^{tm1.1(Ace2)Spo}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(Ace2)Spo}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, S Paul Oh
• MGI ID: MGI:6406372
• Synonyms: ROSA26^Ace2
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(Ace2)Spo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286357
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(Ace2)Spo} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Ace2 (MGI:1917258)

• Mutation details: A FLAG-tagged mouse Ace2 gene, preceded by a loxP-flanked Neomycin-translational STOP cassette, was inserted into the endogenous Gt(ROSA)26Sor locus. The loxP flanked STOP cassette was removed via cre-mediated recombination. Ace2 is expressed at high levels in most tissues of the body. (J:286357)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:286357 Qi YF, et al., Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia. J Mol Med (Berl). 2016 Jan;94(1):37-49
• All: 6 reference(s)