Ace2^em2Shyy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em2Shyy
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 2, John Y J Shyy
• MGI ID: MGI:6406965
• Synonyms: ACE2 S680D KI
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em2Shyy page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-Cas9 genome editing technology was used to modify codon 680 TCC (coding Ser680) to GAC (coding Asp). (J:286356)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:286356 Zhang J, et al., AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 Aug 15;198(4):509-520
• All: 2 reference(s)