Slc6a12^tm1Smoc
Targeted Allele Detail

Summary

• Symbol: Slc6a12^tm1Smoc
• Name: solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; targeted mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6430632
• Gene: Slc6a12 Location: Chr6:121320035-121342734 bp, + strand Genetic Position: Chr6, 57.25 cM, cytoband F1
• Alliance: Slc6a12^tm1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238766
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1 and 2 were replaced by a pGK-Neomycin selection cassette. (J:238766)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc6a12 Mutation: 38 strains or lines available

References

• Original: J:283586 Liu Z, et al., Betaine/GABA transporter-1 (BGT-1) deficiency in mouse prevents acute liver failure in vivo and hepatocytes apoptosis in vitro. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165634
• All: 2 reference(s)