Tg(Tk1-DPP4)27Ysj
Transgene Detail

Summary

• Symbol: Tg(Tk1-DPP4)27Ysj
• Name: transgene insertion 27, Yong-Suk Jang
• MGI ID: MGI:6443611
• Synonyms: hDPP4-Tg
• Transgene: Tg(Tk1-DPP4)27Ysj Location: unknown
• Alliance: Tg(Tk1-DPP4)27Ysj page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Epitope tag, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tk1-DPP4)27Ysj expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DPP4 (1803)

  Dpp4	(MGI:94919)

• Mutation details: The full-length human DPP4 cDNA with an N-terminal Flag tag is under the control of the thymidine kinase promoter. Four lines were established: 2, 10, 17 and 27. This is the highest expressing line with high fertility. Western blot analysis confirmed expression in brain, liver, lung, and intestine. (J:290259)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:290259 Kim J, et al., Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis. J Microbiol Biotechnol. 2020 Mar 28;30(3):427-438
• All: 1 reference(s)