Retreg1^tm1.2Myz
Targeted Allele Detail

Summary

• Symbol: Retreg1^tm1.2Myz
• Name: reticulophagy regulator 1; targeted mutation 1.2, Makoto Miyazaki
• MGI ID: MGI:6450915
• Synonyms: FAM134B KO
• Gene: Retreg1 Location: Chr15:25843266-25973773 bp, + strand Genetic Position: Chr15, 9.59 cM
• Alliance: Retreg1^tm1.2Myz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286809
• Parent Cell Line: EC7.1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129X1/SvJ)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting construct contains an FRT-PGK-neomycin-polyA-FRT followed by a loxP site upstream of the last exon and a second loxP site downstream of the last exon. Flp-mediated recombination removed the FRT-flanked neo cassette. Cre-mediated recombination removed the last exon. (J:286809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Retreg1 Mutation: 29 strains or lines available

References

• Original: J:286809 Kohno S, et al., An N-terminal-truncated isoform of FAM134B (FAM134B-2) regulates starvation-induced hepatic selective ER-phagy. Life Sci Alliance. 2019 Jun;2(3)
• All: 1 reference(s)