Tra2b^em1H
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tra2b^em1H
• Name: transformer 2 beta; endonuclease-mediated mutation 1, Harwell
• MGI ID: MGI:6451746
• Synonyms: TRA2B-FLOX-EM1-B6
• Gene: Tra2b Location: Chr16:22063302-22084755 bp, - strand Genetic Position: Chr16, 13.18 cM
• Alliance: Tra2b^em1H page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• CRISPR-targeting introduced a floxed poisoned exon. (J:90559, J:360846)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tra2b Mutation: 22 strains or lines available

References

• Original: J:360846 Dalgliesh C, et al., An ultra-conserved poison exon in the Tra2b gene encoding a splicing activator is essential for male fertility and meiotic cell division. EMBO J. 2025 Jan 2
• All: 2 reference(s)