Ptges^{tm1.1(PTGES)Bjb}
Targeted Allele Detail

Summary

• Symbol: Ptges^{tm1.1(PTGES)Bjb}
• Name: prostaglandin E synthase; targeted mutation 1.1, Bjorn Bauer
• MGI ID: MGI:6454709
• Synonyms: hmPGES-1
• Gene: Ptges Location: Chr2:30779483-30793309 bp, - strand Genetic Position: Chr2, 21.75 cM
• Alliance: Ptges^{tm1.1(PTGES)Bjb} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294101
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Ptges^{tm1.1(PTGES)Bjb} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTGES (9536)

  Ptges

  (MGI:1927593)

  human cDNA

• Mutation details: Using a BAC from the RPCI-23 library for the targeting vector, the endogenous genomic sequence, starting from the translation initiation site in exon 1 and ending with exon 2, was replaced with a human PTGES mini-gene consisting of the full-length cDNA with human intron 1 inserted between the exon 1 and 2 cDNA sequences. An F3 site flanked puromycin resistance gene cassette was inserted downstream of the mini-gene. This puro cassette was later removed through flp-mediated recombination. (J:294101)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptges Mutation: 47 strains or lines available

References

• Original: J:294101 Soldner ELB, et al., Inhibition of human microsomal PGE2 synthase-1 reduces seizure-induced increases of P-glycoprotein expression and activity at the blood-brain barrier. FASEB J. 2019 Dec;33(12):13966-13981
• All: 1 reference(s)