Irs4^m1
Spontaneous Allele Detail

Summary

• Symbol: Irs4^m1
• Name: insulin receptor substrate 4; mutation 1
• MGI ID: MGI:6455196
• Synonyms: Irs4^BALB/cByJ, Irs4^L683F
• Gene: Irs4 Location: ChrX:140493994-140508213 bp, - strand Genetic Position: ChrX, 62.43 cM
• Alliance: Irs4^m1 page

Mutation origin

• Strain of Origin: BALB/cByJ

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Mutation: Single point mutation
• Mutation details: This mutation is exclusive to the BALB/cByJ sub-strain and not found in BALB/cJ or any other strain tested. It is a C-to-T (on coding reverse strand; g.X:141723152G>A on forward strand) mutation that changes leucine codon 683 to a phenylalanine codon (p.L683F). (J:294207)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irs4 Mutation: 6 strains or lines available

References

• Original: J:294207 Gan P, et al., Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy. Sci Rep. 2020 May 5;10(1):7605
• All: 1 reference(s)