Tg(Myh6-ACE2)1Rbre
Transgene Detail

Summary

• Symbol: Tg(Myh6-ACE2)1Rbre
• Name: transgene insertion 1, Roger E Breitbart
• MGI ID: MGI:6459902
• Transgene: Tg(Myh6-ACE2)1Rbre Location: unknown
• Alliance: Tg(Myh6-ACE2)1Rbre page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-ACE2)1Rbre expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ACE2 (59272)

  Ace2	(MGI:1917258)

• Tg(Myh6-ACE2)1Rbre expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: The human ACE2 cDNA is under the control of the mouse cardiac alpha-myosin heavy chain promoter. Two lines (1 and 2) were generated. Line 1 is a moderate expression line. Western blot analysis confirmed expression in the heart but not in lung, liver, kidney, or spleen. (J:128793)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:128793 Donoghue M, et al., Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. J Mol Cell Cardiol. 2003 Sep;35(9):1043-53
• All: 2 reference(s)