Gli3^tm1.1Utsw
Targeted Allele Detail

Summary

• Symbol: Gli3^tm1.1Utsw
• Name: GLI-Kruppel family member GLI3; targeted mutation 1.1, University of Texas Southwestern Medical Center
• MGI ID: MGI:6478872
• Synonyms: Gli3^TAP
• Gene: Gli3 Location: Chr13:15638308-15904611 bp, + strand Genetic Position: Chr13, 5.43 cM, cytoband A2
• Alliance: Gli3^tm1.1Utsw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279590
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Epitope tag)
• Mutation: Insertion
• Mutation details: The targeting construct inserted at the translation start site a tandem affinity purification (TAP) tag, containing a protein A tag and an HA tag separated by a Tev protease cleavage site. Cre-mediated recombination removed the floxed neomycin cassette downstream of exon 2 . (J:279590)

Expression

In Mice Carrying this Mutation:

1 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli3 Mutation: 81 strains or lines available

References

• Original: J:279590 Zhang Z, et al., A proteomic approach identifies SAFB-like transcription modulator (SLTM) as a bidirectional regulator of GLI family zinc finger transcription factors. J Biol Chem. 2019 Apr 5;294(14):5549-5561
• All: 1 reference(s)