P2rx7tm1d(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
P2rx7tm1d(EUCOMM)Wtsi |
Name: |
purinergic receptor P2X, ligand-gated ion channel, 7; targeted mutation 1d, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:6489963 |
Gene: |
P2rx7 Location: Chr5:122781974-122829495 bp, + strand Genetic Position: Chr5, 62.5 cM, cytoband F
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Alliance: |
P2rx7tm1d(EUCOMM)Wtsi page
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IMPC: |
P2rx7 gene page |
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Germline Transmission: |
Earliest citation of germline transmission:
J:299014
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: The L1L2_Bact_P cassette was inserted at position 122790326 of Chromosome 5 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 122791229. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:299014)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any P2rx7 Mutation: |
52 strains or lines available
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Original: |
J:299014 Conte G, et al., P2X7 Receptor-Dependent microRNA Expression Profile in the Brain Following Status Epilepticus in Mice. Front Mol Neurosci. 2020;13:127 |
All: |
9 reference(s) |
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