Tg(Col2a1-tTA)HNono
Transgene Detail

Summary

• Symbol: Tg(Col2a1-tTA)HNono
• Name: transgene insertion H, Noriaki Ono
• MGI ID: MGI:6490616
• Synonyms: Col2a1-tTA
• Transgene: Tg(Col2a1-tTA)HNono Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Tg(Col2a1-tTA)HNono page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL/J)F1

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The 8.4kb construct incorporates the mouse Col2a1 promoter and a fragment of intron 1 ligated to a splice acceptor sequence followed by an internal ribosomeentry site (IRES), tetracyclinecontrolled transactivator (tTA), and the SV40 large T antigen polyadenylation signal. A single copy of the transgene was inserted 16 kb downstream of Peli2 on mouse Chromosome 14. Line H is the high expresser line. (J:320594)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:320594 Hallett SA, et al., Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment. Elife. 2021 Jul 26;10:e64513
• All: 1 reference(s)