Ace2^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ace2^em1Cya
• Name: angiotensin converting enzyme 2; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6500740
• Synonyms: Ace2^em1Cgen, Ace2^em1cyagen
• Gene: Ace2 Location: ChrX:162922338-162971414 bp, + strand Genetic Position: ChrX, 76.12 cM, cytoband F5
• Alliance: Ace2^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a deletion of exons 3 to 18. RT-PCR and Western blot analysis confirmed absence of mRNA and protein in the colon. (J:299383)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ace2 Mutation: 66 strains or lines available

References

• Original: J:299383 Yu W, et al., ACE2 contributes to the maintenance of mouse epithelial barrier function. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1276-1282
• All: 1 reference(s)