Dhx15em1Flv
Endonuclease-mediated Allele Detail
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Symbol: |
Dhx15em1Flv |
Name: |
DEAH-box helicase 15; endonuclease-mediated mutation 1, Richard A Flavell |
MGI ID: |
MGI:6507764 |
Synonyms: |
Dhx15f |
Gene: |
Dhx15 Location: Chr5:52307545-52347856 bp, - strand Genetic Position: Chr5, 27.51 cM, cytoband C1
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Alliance: |
Dhx15em1Flv page
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Strain of Origin: |
Not Applicable
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Allele Type: |
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Endonuclease-mediated (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: LoxP sites were inserted upstream of exon 1 and into intron 3 using two gRNAs (targeting TGAACTGCAGCAGCGTTCCT and AGATATTATTAGAGTAGCCG) and two ssODN templates with CRISPR/Cas9 technology, creating a conditional-ready allele with exons 1-3 floxed.
(J:302140)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Dhx15 Mutation: |
39 strains or lines available
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Original: |
J:302140 Wang Y, et al., The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2017432118 |
All: |
1 reference(s) |
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