Trp53^tm3.1Thst
Targeted Allele Detail

Summary

• Symbol: Trp53^tm3.1Thst
• Name: transformation related protein 53; targeted mutation 3.1, Thorsten Stiewe
• MGI ID: MGI:6507841
• Synonyms: Trp53^S180A
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm3.1Thst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302502
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: The targeting construct introduced a mutation (TCC to GCC) resulting in the amino acid substitution of serine with alanine at position 180 (p.S180A) and inserted a loxP site flanked STOP/selection cassette. Cre-mediated recombination removed the STOP/selection cassette. (J:302502)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:302502 Timofeev O, et al., Phosphorylation Control of p53 DNA-Binding Cooperativity Balances Tumorigenesis and Aging. Cancer Res. 2020;80(23):5231-5244
• All: 1 reference(s)