Kiss1^tm1.2Nurep
Targeted Allele Detail

Summary

• Symbol: Kiss1^tm1.2Nurep
• Name: KiSS-1 metastasis-suppressor; targeted mutation 1.2, Lab. of Reproductive Science
• MGI ID: MGI:6508039
• Synonyms: KJiss1^-
• Gene: Kiss1 Location: Chr1:133254950-133257460 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Kiss1^tm1.2Nurep page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:295986
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neomycin resistance cassette inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and exon 3. (J:296176)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kiss1 Mutation: 22 strains or lines available

References

• Original: J:295986 Goto T, et al., Testosterone Supplementation Rescues Spermatogenesis and In Vitro Fertilizing Ability of Sperm in Kiss1 Knockout Mice. Endocrinology. 2020 Sep 1;161(9)
• All: 2 reference(s)