n-TIaat17^em1Slac
Endonuclease-mediated Allele Detail

Summary

• Symbol: n-TIaat17^em1Slac
• Name: nuclear encoded tRNA isoleucine 17 (anticodon TAT); endonuclease-mediated mutation 1, Susan L Ackerman
• MGI ID: MGI:6510838
• Synonyms: nTi17^-
• Gene: n-TIaat17 Location: Chr17:84169373-84169465 bp, + strand Genetic Position: Chr17, Syntenic
• Alliance: n-TIaat17^em1Slac page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 15 bp deletion (AATCGGTTAGCGCGC) was created using sgRNAs targeting the 5' end of the gene with CRISPR/Cas9 technology. (J:297745)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any n-TIaat17 Mutation: 0 strains or lines available

References

• Original: J:297745 Kapur M, et al., Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility. Neuron. 2020 Oct 14;108(1):193-208.e9
• All: 1 reference(s)