Hprt1tm1(GRN)Blrl
Targeted Allele Detail
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Symbol: |
Hprt1tm1(GRN)Blrl |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Blair R Leavitt |
MGI ID: |
MGI:6512847 |
Synonyms: |
GRNTg |
Gene: |
Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
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Alliance: |
Hprt1tm1(GRN)Blrl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:303265
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Hprt1tm1(GRN)Blrl expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
GRN (2896) |
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Mutation details: The targeting construct is created using bacterial artificial chromosome RP11-1145H1, carrying a 170 kb insert from human chromosome 17. The BAC includes the entire GRN coding sequence (8 kb) plus approximately 8 kb of upstream sequence. The 35 kb construct including Hprt homologous recombination targeting arms was inserted into the Hprt locus.
(J:303265)
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Original: |
J:303265 Petkau TL, et al., Human progranulin-expressing mice as a novel tool for the development of progranulin-modulating therapeutics. Neurobiol Dis. 2021 Feb 24;153:105314 |
All: |
2 reference(s) |
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