Il17a^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il17a^em1Cya
• Name: interleukin 17A; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:6695195
• Synonyms: Il17a^em1Cgen, l17a^em1cyagen
• Gene: Il17a Location: Chr1:20801129-20804720 bp, + strand Genetic Position: Chr1, 6.45 cM, cytoband A
• Alliance: Il17a^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination created an approximately 212 bp deletion. Western blot analysis confirmed the absence of expression in lung and liver tissue from homozygous mice. (J:304178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17a Mutation: 25 strains or lines available

References

• Original: J:304178 Lin X, et al., ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. iScience. 2021 Apr 23;24(4):102293
• All: 1 reference(s)