Casq2^tm2.1Kpfe
Targeted Allele Detail

Summary

• Symbol: Casq2^tm2.1Kpfe
• Name: calsequestrin 2; targeted mutation 2.1, Karl Pfeifer
• MGI ID: MGI:6711695
• Synonyms: Casq2RevFlox, rCasq2
• Gene: Casq2 Location: Chr3:101993731-102053830 bp, + strand Genetic Position: Chr3, 44.3 cM, cytoband F3
• Alliance: Casq2^tm2.1Kpfe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261728
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert loxP66 and loxP71 inward facing sites flanking the promoter and first exon of the gene (from -561 to +538bp); they are inverted relative to their normal endogenous orientation. An FRT-flanked neomycin resistance (neo) cassette was inserted in intron 1, between exons 1 and 2. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:261728)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Casq2 Mutation: 34 strains or lines available

References

• Original: J:261728 Flores DJ, et al., Conditional ablation and conditional rescue models for Casq2 elucidate the role of development and of cell-type specific expression of Casq2 in the CPVT2 phenotype. Hum Mol Genet. 2018 May 1;27(9):1533-1544
• All: 2 reference(s)