Atoh1^{tm8.1(flpo)Hzo}
Targeted Allele Detail

Summary

• Symbol: Atoh1^{tm8.1(flpo)Hzo}
• Name: atonal bHLH transcription factor 1; targeted mutation 8.1, Huda Y Zoghbi
• MGI ID: MGI:6717359
• Synonyms: Atoh1^FlpO
• Gene: Atoh1 Location: Chr6:64706109-64708229 bp, + strand Genetic Position: Chr6, 30.03 cM
• Alliance: Atoh1^{tm8.1(flpo)Hzo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:268187
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Atoh1^{tm8.1(flpo)Hzo} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Atoh1 (MGI:104654)

• Mutation details: A FlpO-lox2722-PGK-Neo-lox2722 cassette was used to replace the coding sequence of the mouse Atoh1 gene, leaving the transcriptional start site intact by homologous recombination in ES cells. The PGK-neo cassette was removed by crossing with cre expressing mouse. (J:268187)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Atoh1 (mouse) Summary of all recombinase alleles driven by Atoh1. Alliance mouse Atoh1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atoh1 Mutation: 36 strains or lines available

References

• Original: J:268187 van der Heijden ME, et al., Loss of Atoh1 from neurons regulating hypoxic and hypercapnic chemoresponses causes neonatal respiratory failure in mice. Elife. 2018 Jul 4;7:e38455
• All: 2 reference(s)