H19^em1Kpfe
Endonuclease-mediated Allele Detail

Summary

• Symbol: H19^em1Kpfe
• Name: H19, imprinted maternally expressed transcript; endonuclease-mediated mutation 1, Karl Pfeifer
• MGI ID: MGI:6720924
• Synonyms: H19deltaLet7
• Gene: H19 Location: Chr7:142129267-142131883 bp, - strand Genetic Position: Chr7, 87.97 cM
• Alliance: H19^em1Kpfe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307416
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intergenic deletion
• Mutation details: CRISPR-targeting deleting 25 and 48 bp sequences within exons 1 and exon 4 to eliminate binding sites for Mirlet7e, Mirlet7g, and Mirlet7i. (J:307416)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H19 Mutation: 12 strains or lines available

References

• Original: J:307416 Park K-S, et al., Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA. bioRxiv. 2021
• All: 1 reference(s)