Usp36^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Usp36^{tm1c(EUCOMM)Hmgu}
• Name: ubiquitin specific peptidase 36; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6721049
• Synonyms: USP36^lox
• Gene: Usp36 Location: Chr11:118150477-118181070 bp, - strand Genetic Position: Chr11, 83.06 cM
• Alliance: Usp36^{tm1c(EUCOMM)Hmgu} page
• IMPC: Usp36 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307419
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 118169843 of Chromosome 11 upstream of exon 6 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 6 at position 118170516. Exon 6 is thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase mediated removal of the lacZ and neo cassettes. (J:307419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp36 Mutation: 46 strains or lines available

References

• Original: J:307419 Ryu H, et al., The deubiquitinase USP36 promotes snoRNP group SUMOylation and is essential for ribosome biogenesis. EMBO Rep. 2021 Apr 14;:e50684
• All: 1 reference(s)