Tg(Myh6-Akt1*)6445Gcon
Transgene Detail
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Symbol: |
Tg(Myh6-Akt1*)6445Gcon |
Name: |
transgene insertion 6445, Gianluigi Condorelli |
MGI ID: |
MGI:6721418 |
Synonyms: |
alphaMHC-Akttg, CAkttg, E40K-Akt |
Transgene: |
Tg(Myh6-Akt1*)6445Gcon Location: unknown
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Alliance: |
Tg(Myh6-Akt1*)6445Gcon page
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Strain of Origin: |
Not Applicable
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Transgene Type: |
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Transgenic (Constitutively active, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-Akt1*)6445Gcon expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Akt1 (MGI:87986) |
mouse promoter and cDNA |
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Mutation details: This transgene insert contains the following elements: mouse cardiac muscle myosin heavy polypeptide 6 alpha promoter sequence to drive the heart-specific expression of a constitutively active mutated form of the mouse thymoma viral proto-oncogene 1 cDNA where codon 40 was changed from glutamic acid to lysine (p.E40K) through a G-to-A point mutation (c.118G>A), and SV40 intron and poly(A) signal sequences.
(J:258598)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:258598 Condorelli G, et al., Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12333-8 |
All: |
6 reference(s) |
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