Lyz1^{em1(dre/ERT2)Smoc}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lyz1^{em1(dre/ERT2)Smoc}
• Name: lysozyme 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6724277
• Synonyms: Lyz1-2A-DreER, Lyz1-2A-DreERT2, Lyz1^{em1(2A-DreERT2)Smoc}
• Gene: Lyz1 Location: Chr10:117123702-117128773 bp, - strand Genetic Position: Chr10, 65.35 cM
• Alliance: Lyz1^{em1(dre/ERT2)Smoc} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Lyz1^{em1(dre/ERT2)Smoc} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Lyz1 (MGI:96902)

• Mutation details: A 2A-DreERT2 expression cassette was knocked into the Lyz1 gene stop codon site via CRISPR/Cas mediated recombination. (J:238766, J:304636)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lyz1 (mouse) Summary of all recombinase alleles driven by Lyz1. Alliance mouse Lyz1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyz1 Mutation: 14 strains or lines available

References

• Original: J:304636 Han X, et al., A suite of new Dre recombinase drivers markedly expands the ability to perform intersectional genetic targeting. Cell Stem Cell. 2021 Feb 2
• All: 2 reference(s)