Prxl2btm1.1Ksak
Targeted Allele Detail
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Symbol: |
Prxl2btm1.1Ksak |
Name: |
peroxiredoxin like 2B; targeted mutation 1.1, Kenji Sakimura |
MGI ID: |
MGI:6728797 |
Synonyms: |
PM/PGFSflox, Prxl2btm1.1Dfwo |
Gene: |
Prxl2b Location: Chr4:154980884-154983522 bp, - strand Genetic Position: Chr4, 85.67 cM
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Alliance: |
Prxl2btm1.1Ksak page
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Germline Transmission: |
Earliest citation of germline transmission:
J:307536
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Parent Cell Line: |
RENKA (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A loxP site was inserted 139 bp upstream of exon 2 and an FRT-flanked PGK promoter-driven neopoly cassette and second loxP site were inserted downstream of exon 3. Cre-mediated recombination removed the selection cassette and left exons 2-3 floxed.
(J:307536)
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Original: |
J:307536 Bertrand JA, et al., Deletion of the gene encoding prostamide/prostaglandin F synthase reveals an important role in regulating intraocular pressure. Prostaglandins Leukot Essent Fatty Acids. 2021 Feb;165:102235 |
All: |
1 reference(s) |
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