Strip2^tm1.2Tac
Targeted Allele Detail

Summary

• Symbol: Strip2^tm1.2Tac
• Name: striatin interacting protein 2; targeted mutation 1.2, Taconic
• MGI ID: MGI:6755525
• Synonyms: Myoscape^-, Myoscape KO
• Gene: Strip2 Location: Chr6:29917011-29959680 bp, + strand Genetic Position: Chr6, 12.36 cM
• Alliance: Strip2^tm1.2Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:306481
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LoxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 2 and an F3 site flanked puromycin resistance gene cassette and a second loxP site into intron 8. The neo and puro cassettes were removed through subsequent flp-mediated recombination and exons 3-8 were deleted through cre-mediated recombination. Absence of peptide expression from this allele was confirmed by western blots. (J:306481)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Strip2 Mutation: 48 strains or lines available

References

• Original: J:306481 Eden M, et al., Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nat Commun. 2016 Apr 28;7:11317
• All: 1 reference(s)