Tet3^tm1Wrk
Targeted Allele Detail

Summary

• Symbol: Tet3^tm1Wrk
• Name: tet methylcytosine dioxygenase 3; targeted mutation 1, Wolf Reik
• MGI ID: MGI:6759409
• Synonyms: Tet3^loxP
• Gene: Tet3 Location: Chr6:83339355-83434190 bp, - strand Genetic Position: Chr6, 35.94 cM
• Alliance: Tet3^tm1Wrk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299422
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 5 was flanked by loxP sites. This exon encodes residues required for chelation of Fe(II) and is upstream of exons containing other key catalytic residues. (J:299422)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet3 Mutation: 59 strains or lines available

References

• Original: J:299422 Santos F, et al., Active demethylation in mouse zygotes involves cytosine deamination and base excision repair. Epigenetics Chromatin. 2013 Nov 14;6(1):39
• All: 3 reference(s)