Mapk1^tm3Moga
Targeted Allele Detail

Summary

• Symbol: Mapk1^tm3Moga
• Name: mitogen-activated protein kinase 1; targeted mutation 3, Masato Ogata
• MGI ID: MGI:6759774
• Synonyms: ERK2 floxSem, Mapk1^{tm3(D319N)Moga}
• Gene: Mapk1 Location: Chr16:16801246-16865317 bp, + strand Genetic Position: Chr16, 10.53 cM
• Alliance: Mapk1^tm3Moga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104881
• Parent Cell Line: EB3/5 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct inserted a floxed IRES-beta-geo fusion cassette, floxed exons 2, a partial cDNA starting from exon 3 to the end of the polyadenylation signal sequence encoding the amino acid substitution of aspartic acid with arginine at position 319 (D319N), and a neomycin resistance cassette. After removing the gene trap cassette by the cre recombinase, the allele expresses a modified protein product with the amino acid substitution. (J:104881)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk1 Mutation: 40 strains or lines available

References

• Original: J:104881 The RIKEN BioResource Center, Information obtained from The RIKEN BioResource Center. Unpublished. 2006-2013
• All: 1 reference(s)