Pax9^{tm1.1(cre)Sbam}
Targeted Allele Detail

Summary

• Symbol: Pax9^{tm1.1(cre)Sbam}
• Name: paired box 9; targeted mutation 1.1, Simon Bamforth
• MGI ID: MGI:6760663
• Synonyms: Pax9Cre
• Gene: Pax9 Location: Chr12:56738552-56759607 bp, + strand Genetic Position: Chr12, 24.53 cM
• Alliance: Pax9^{tm1.1(cre)Sbam} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284143
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Pax9^{tm1.1(cre)Sbam} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax9 (MGI:97493)

• Mutation details: The targeting construct was designed to replace a 1.06 kb section of the mouse Pax9 gene, spanning the second half of exon two, containing the start codon, and the first half of the 3rd exon, containing the paired box and octapeptide motif, with a promoterless Cre recombinase gene preceded by a consensus Kozak sequence and the FRT-flanked PGK-Neomycin cassette. After homologous recombination in ES cells, the FRT-flanked PGK-neomycin cassette was removed by crossing the derived mice with FLPe mice. (J:284143)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax9 (mouse) Summary of all recombinase alleles driven by Pax9. Comparative matrix view of recombinase activities Alliance mouse Pax9 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pax9 Mutation: 17 strains or lines available

References

• Original: J:284143 Phillips HM, et al., Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis. Development. 2019 Sep 23;146(18):dev177618
• All: 3 reference(s)